Medications to Treat Mast Cell Diseases

ALL PATIENTS:

Self-Injectable Epinephrine (two doses; e.g., EpiPen®/EpiPen Jr®) should be carried by all patients with a mast cell disorder at all times, even if previous anaphylaxis has not occurred. Both the patient and family members/caregivers should be trained on administering the epinephrine!

Please visit the American Academy of Allergy, Asthma and Immunology (AAAAI) website for more information on anaphylaxis.

Basic Medications for Symptomatic Patients with Mast Cell Diseases^1-4

• H1 antihistamines: help with itching, abdominal pain, flushing, headaches, brain fog
• H2 antihistamines: help with gastrointestinal symptoms and overall mast cell stability (all mast cell activation symptoms)
• Mast cell stabilizers: help with stomach and intestinal symptoms and brain fog
• Leukotriene inhibitors: help with respiratory symptoms and overall mast cell stability (all mast cell activation symptoms)
• Aspirin therapy (under direct supervision of a physician): if tolerated and if prostaglandins are elevated, helps with flushing, brain fog and bone pain

Note: The H1 and H2 antihistamines are necessary to stabilize receptors on the mast cell. Therefore, if additional medication is required for control of gastroesophageal reflux (GERD), a proton pump inhibitor may be added to this protocol, but it cannot replace the H2 antihistamine.

Please see Tables 1-6 for lists of some specific drugs in these different categories.

Please see Table 7 for a list of some specific drugs for advanced systemic mastocytosis.

Table 1. Some First Generation H1 Antihistamines

Table 2. Some Second Generation H1 Antihistamines (may tend to cause less drowsiness)

*Zaditor® is only available in the US as eye drops; Zaditen® is available by prescription, but it must be obtained from a compounding pharmacy or from abroad.

Table 3. Some H2 Antihistamines

Table 4. Some Leukotriene Inhibitors

Table 5. Mast Cell Stabilizers

* Zaditor® is only available in the US as eye drops; Zaditen® is available by prescription, but it must be obtained from a compounding pharmacy or from abroad.

Table 6. Proton Pump Inhibitors to Help with GERD (Gastroesophageal Reflux)

Table 7. Targeted Therapies/ Small Molecule Inhibitors may be prescribed for Selected Patients with Smoldering and Advanced Variants of Systemic Mastocytosis^{1, 5}

Table 8. Conventional Chemotherapy that may be prescribed for Selected Patients with Smoldering and Advanced Variants of Systemic Mastocytosis^{1, 5}

Table 9. Immunotherapy that may be prescribed for Selected Patients with Smoldering and Advanced Variants of Systemic Mastocytosis^{1, 5}

There are several more therapies in the pipeline, including additional tyrosine kinase inhibitors and other targeted therapies.

Sometimes symptoms change, and it becomes necessary to increase or decrease doses of medications, or to add additional medications to a patient’s prescribed protocol. The simplest change made in conjunction with your mast cell specialist can make such a difference in your symptoms! Although it is tempting to change dosing regimens on your own, please always work with your physician to achieve the safest, most effective outcome!