Research GrantsTMS awards grant funding for mastocytosis and mast cell activation syndrome (MCAS) research. Below is a list of our award recipients from recent years. This page will be updated as new publications or presentations related to TMS-funded research are identified.Open GrantsGrant Awards Currently Under ConsiderationThe Mast Cell Disease Society does not have any open grants at this time. When there are open grant applications, they will be listed here.Coming soon……TMS thanks all of those listed below and previous awardees for their dedication to advance our understanding of mast cell diseases.Research Grant Awardees2023 American Academy of Allergy, Asthma and Immunology (AAAAI)/TMS Research Award in Mast Cell Disorders Including Mastocytosis and Mast Cell Activation SyndromeThis grant award was funded equally in partnership by TMS & AAAAI. Award amount$60,000Award recipientJennifer Nicoloro-SantaBarbara, PhD with Brigham and Women’s Hospital (BWH)TitleBehavioral and biological mechanism underlying depression in mast cell disorders.2021 American Academy of Allergy, Asthma and Immunology (AAAAI)/TMS Research Award in Mast Cell Disorders Including Mastocytosis and Mast Cell Activation SyndromeThis grant award was funded equally in partnership by TMS & AAAAI. Award amount$60,000Award recipientDr. Daniel Dwyer with Brigham and Women’s Hospital (BWH)TitleSingle-cell characterization of cutaneous mast cells in mastocytosis and hereditary alpha-tryptasemia.2019 American Academy of Allergy, Asthma and Immunology (AAAAI)/TMS Research Award in Mast Cell Disorders Including Mastocytosis and Mast Cell Activation SyndromeThis grant award was funded equally in partnership by TMS & AAAAI.Award amount$60,000Award recipientMatthew Hamilton, MDBrigham and Women’s Hospital Mastocytosis CenterHarvard University, Boston, MACo-investigatorsMariana Castells, MD, PhDPeter Novak, MD, PhDOlga Pozdnyakova, MD, PhDSarah Glover, DO, of the University of MississippiTitleA Novel Approach to Characterize and Focus Treatment in Patients with MCAS and Dysautonomia2018 TMS Research Award in Pediatric Mastocytosis, Including Related Disorders of Pediatric Mast Cell Activation – Catalano Family Grant Through Wyatt’s WarriorsThis grant award was funded by TMS, thanks to a generous donation from the Catalano Family through Wyatt’s Warriors.Award amount$50,000Award recipientAnupama Ravi, MDMayo Clinic Program for the Study of Mast Cell and Eosinophil DisordersDivision of Pediatric Allergy and ImmunologyMayo Clinic, Rochester, MNCo-investigatorsJoseph Butterfield, MDJeffrey Meeusen, PhDLeslie Donato, PhDAngela Mattke, MDMayo Clinic, Rochester, MNTitleExcretion of Mast Cell Mediators in Pediatric Mastocytosis and Mast Cell Activation Syndrome (MCAS)2018 TMS Research Award in Pediatric Mastocytosis, Including Related Disorders of Pediatric Mast Cell Activation – Karen and Jim Houghton GrantThis grant award was funded by TMS, thanks to a generous donation from Karen and Jim Houghton.Award amount$60,000Award recipientOlivier Hermine, MD, PhD, and Leila Maouche Chrétien, PhDNecker Children’s Hospital/Imagine Institute, National Reference Center of Mastocytosis, Paris, FranceTitleTranslational Studies on Pediatric Mastocytosis for Identification of New Pathways of Transformation and of New Potentially Effective Treatment of Both Pediatric and Adult MastocytosisResulting Publications/PresentationsL. Polivka, V. Parietti, J. Bruneau, E. Soucie, M. Madrange, E. Bayard, R. Rignault, D. Canioni, S. Fraitag, L. Lhermitte, M. Feroul, M. Tissandier, J. Rossignol, L. Frenzel, N. Cagnard, C. Meni, H. Bouktit, A.-F. Collange, C. Gougoula, M. Parisot, B. Bader-Meunier, C. Livideanu, C. Laurent, M. Arock, S. Hadj-Rabia, U. Rüther, P. Dubreuil, C. Bodemer, O. Hermine, L. Maouche-Chrétien,The association of Greig syndrome and mastocytosis reveals the involvement of the hedgehog pathway in advanced mastocytosis, Blood, Volume 138, Issue 23, 2021, Pages 2396-24072018 TMS Research Award in Pediatric Mastocytosis, Including Related Disorders of Pediatric Mast Cell Activation – Karen and Jim Houghton GrantThis grant award was funded by TMS, thanks to a generous donation from Karen and Jim Houghton.Award amount$60,000Award recipientMatthew Giannetti, MDCo-investigatorMariana Castells, MD, PhDDepartment of Rheumatology, Allergy, and ImmunologyCenter of Excellence for MastocytosisBrigham and Women’s HospitalBoston, MATitleIdentification of Novel Pathways in the Transcriptome of Human Mast Cells from Children and Adults with Cutaneous Mastocytosis2017 TMS/AAAAI Research Award in Mastocytosis and/or Mast Cell Activation SyndromeThis grant award is a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology (AAAAI), with each organization contributing $30,000.Award amount$60,000Award recipientJeremy O’Sullivan, PhDDivision of Allergy/ImmunologyNorthwestern University Feinberg School of MedicineTitleTargeting Mast Cells through Siglec-62015 TMS/Artrusttm Research Award in Mastocytosis and/or Mast Cell Activation SyndromeThis grant award was a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology, with each organization contributing $30,000.Award amount$60,000Award recipientJonathan Lyons, MDAssistant Clinical InvestigatorGenetics and Pathogenesis SectionLaboratory of Allergic DiseasesNational Institute of Allergy & Infectious Diseases/National Institutes of HealthTitleConvergence of Autosomal Dominant Familial Tryptasemia and Mast Cell Associated DisordersResulting Publication(s)/Presentation(s)Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 Dec;48(12):1564-9.Lyons JJ, Stotz SC, Chovanec J, Liu Y, Lewis KL, Nelson C, DiMaggio T, Jones N, Stone KD, Sung H, Biesecker LG, Colicos MA, Milner JD. A common haplotype containing functional CACNA1H variants is frequently coinherited with increased TPSAB1 copy number. Genet Med. Sep 21 2017.2015 TMS Research Award in Mastocytosis and Mast Cell Activation SyndromeThis grant award was funded by TMS.Award amount$10,000Award recipientCelalettin Ustun, MDAssociate Professor, Department of MedicineDivision of Hematology, Oncology and TransplantationUniversity of MinnesotaTitleMastocytosis in Acute Myelogenous Leukemia (AML) with Core Binding Factors (CBF)Resulting Publication(s)/Presentation(s)13th Annual Meeting of the European Competence Network on Mastocytosis –Munich, Germany, October 8-10, 2015TitleOccult Mastocytosis and KIT D816V in CBF AMLUstun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, et al. Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit). Cancer Med. 2018; 1-9.2014 TMS/Artrust™ Research Award in Mastocytosis and/or Mast Cell Activation SyndromeThis grant award was a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology, with each organization contributing $30,000.Award amount$60,000Award recipientTanya Laidlaw, MDAssistant Professor of Medicine, Harvard Medical SchoolAssociate Physician, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s HospitalTitleCharacterization of a Novel Growth and Survival Factor for Human Mast Cells2014 TMS/Mastokids Research Award in Pediatric Mastocytosis and Pediatric Mast Cell Activation SyndromeThis grant award was a joint offering from TMS and Mastokids, with $20,000 contributed from TMS and $20,000 from Mastokids.Award amount$40,000Award recipientRichard Stevens, PhD, Professor of Medicine, Harvard Medical SchoolCollaboratorsMariana Castells, MD, PhD, Brigham and Women’s HospitalMatthew Hamilton, MD, Brigham and Women’s Hospital(current Principal Investigator of grant)Steven Krilis, MD, PhD, University New South Wales (AUS)TitleImportance of hTryptase-beta in Pediatric Mast Cell DisordersResulting Publication(s)/Presentation(s)CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide. Zhou S, Tanaka K, O’Keeffe M, Qi M, El-Assaad F, Weaver JC, et al. PLoS One. 2016 Mar 16;11(3) 2014 TMS Research Award in Mastocytosis and Mast Cell Activation SyndromeThis grant award was funded by TMS.Award amount$25,000Award recipientTheoharis Theoharides, MS, PhD, MDProfessor of Pharmacology, Internal Medicine (Allergy) and BiochemistryTufts University, School of MedicineTitleLevels of CRH, NT, SP and IL-33 in the serum of systemic mastocytosis and mast cell activation syndrome patients2013 TMS/Mastokids Research Award in Pediatric Mastocytosis and Pediatric Mast Cell Activation SyndromeThis grant award was a joint offering from TMS and Mastokids, with $35,000 contributed from TMS and $25,000 from Mastokids.Award amount$60,000Award recipientLawrence Schwartz, MD, PhDProfessor of Medicine, Microbiology & Immunology, & PathologyDepartment of Internal MedicineVirginia Commonwealth UniversityTitleMonocyte Derived Immunosupressant Cells Inhibit Immune Regulation of Mast Cells in Mastocytosis2011 TMS Research AwardThis grant award was funded by TMS.Award amount$52,516Award recipientLawrence Afrin, MDAssociate Professor of MedicineDivision of Hematology/OncologyMedical University of South Carolina (MUSC)(Currently Division of Hematology, Oncology, and Transplantation, University of Minnesota)CollaboratorsJohn Lazarchick, MD, MUSCSally Self, M.D., MUSCElizabeth Hill, Ph.D., MUSCTitleCharacterization of Certain Peripheral Blood Cell Abnormalities Potentially Aiding the Diagnosis of Mast Cell Activation Syndrome (MCAS)Resulting Publication(s)/Presentation(s)Afrin LB, Self S, Menk J, Lazarchick J. Characterization of Mast Cell Activation Syndrome. Am J Med Sci 2017, in press, DOI: 10.1016/j.amjms.2016.12.013.Afrin LB, Self S, Menk J, Lazarchick J. Characterization of Mast Cell Activation Syndrome. Blood 2016 128:3683.Afrin LB, Butterfield JH, Raithel M, Molderings GJ. Often seen, rarely recognized: mast cell activation disease–a guide to diagnosis and therapeutic options. Ann Med. 2016;48(3):190-201.Afrin LB, Wan Z, Hill EG. Characterization Of Common Blood Test Abnormalities Potentially Aiding Diagnosis Of Mast Cell Activation Syndrome: A Preliminary Analysis. Blood 2013 122:5240.2010 TMS Research AwardThis grant award was funded by TMS.Award amount$50,000Award recipientPeter Valent, MDKaroline Gleixner, MDMedical University of ViennaTitleIdentification of a new target pathway in neoplastic mast cells as basis for the design of a novel pharmacologic conceptResulting Publication(s)/Presentation(s)Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hormann G, Rix U, Bennett KL, et al. KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood. 2011 Aug 18;118(7):1885-98.2010 TMS Research AwardThis grant award was funded by TMS.Award amount$9,756Award recipientsJonathan Smith, MDMelissa Snyder, PhDMichael Cutrer, MDJoseph Butterfield, MDMayo Clinic, Rochester, MNTitleCerebrospinal Fluid Tryptase and Neuropsychiatric Symptoms in Systemic MastocytosisResulting Publication(s)/Presentation(s)Smith JH, Snyder MR, Weiler CR, Cutrer FM, Butterfield JH. Lack of evidence for intrathecal tryptase synthesis in patients with systemic mastocytosis. 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