TMS Research Grant Awards: 2010 – 2017

Apr 02, 2017

The Mastocytosis Society, Inc. (TMS) awards grant funding for mastocytosis and mast cell activation syndrome (MCAS) research. Below is a list of our award recipients from recent years. This page will be updated as new publications or presentations related to TMS-funded research are identified.

TMS thanks all of those listed below and previous awardees for their dedication to mast cell disorder research!


2017 TMS/AAAAI Research Award in Mastocytosis and/or Mast Cell Activation Syndrome

This grant award is a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology (AAAAI), with each organization contributing $30,000.

Award amount:   $60,000

Award recipient: 

Jeremy O’Sullivan, PhD

Division of Allergy/Immunology

Northwestern University Feinberg School of Medicine

Title: Targeting Mast Cells through Siglec-6


2015 TMS/ARTrustTM Research Award in Mastocytosis and/or Mast Cell Activation Syndrome

This grant award was a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology, with each organization contributing $30,000.

Award amount:   $60,000

Award recipient:   

Jonathan Lyons, MD

Assistant Clinical Investigator

Genetics and Pathogenesis Section

Laboratory of Allergic Diseases

National Institute of Allergy & Infectious Diseases/National Institutes of Health

Title:    Convergence of Autosomal Dominant Familial Tryptasemia and Mast Cell Associated Disorders

Resulting Publication(s)/Presentation(s):

Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 Dec;48(12):1564-9.


2015 TMS Research Award in Mastocytosis and Mast Cell Activation Syndrome

This grant award was funded by TMS.

Award amount:   $10,000

Award recipient:   

Celalettin Ustun, MD

Associate Professor, Department of Medicine

Division of Hematology, Oncology and Transplantation

University of Minnesota

Title:   Mastocytosis in Acute Myelogenous Leukemia (AML) with Core Binding Factors (CBF)

Resulting Publication(s)/Presentation(s):

13th Annual Meeting of the European Competence Network on Mastocytosis –Munich, Germany, October 8-10, 2015

Title: Occult Mastocytosis and KIT D816V in CBF AML


2014 TMS/ARTrustTM Research Award in Mastocytosis and/or Mast Cell Activation Syndrome

This grant award was a 1 year joint offering from TMS and the American Academy of Allergy, Asthma and Immunology, with each organization contributing $30,000.

Award amount:         $60,000

Award recipient:

Tanya Laidlaw, MD

Assistant Professor of Medicine, Harvard Medical School

Associate Physician, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital

Title:   Characterization of a Novel Growth and Survival Factor for Human Mast Cells


2014 TMS/Mastokids Research Award in Pediatric Mastocytosis and Pediatric Mast Cell Activation Syndrome

This grant award was a joint offering from TMS and Mastokids, with $20,000 contributed from TMS and $20,000 from Mastokids.

Award amount:   $40,000

Award recipient:

Richard Stevens, PhD, Professor of Medicine, Harvard Medical School

Collaborators:  Mariana Castells, MD, PhD, Brigham and Women’s Hospital

Matthew Hamilton, MD, Brigham and Women’s Hospital

(current Principal Investigator of grant)

Steven Krilis, MD, PhD, University New South Wales (AUS)

Title:   Importance of hTryptase-beta in Pediatric Mast Cell Disorders

Resulting Publication(s)/Presentation(s):

CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide. Zhou S, Tanaka K, O’Keeffe M, Qi M, El-Assaad F, Weaver JC, et al. PLoS One. 2016 Mar 16;11(3) 


2014 TMS Research Award in Mastocytosis and Mast Cell Activation Syndrome

This grant award was funded by TMS.

Award amount:   $25,000

Award recipient:

Theoharis Theoharides, MS, PhD, MD

Professor of Pharmacology, Internal Medicine (Allergy) and Biochemistry

Tufts University, School of Medicine

Title:   Levels of CRH, NT, SP and IL-33 in the serum of systemic mastocytosis and mast cell activation syndrome patients


2013 TMS/Mastokids Research Award in Pediatric Mastocytosis and Pediatric Mast Cell Activation Syndrome

This grant award was a joint offering from TMS and Mastokids, with $35,000 contributed from TMS and $25,000 from Mastokids.

Award amount:   $60,000

Award recipient:

Lawrence Schwartz, MD, PhD

Professor of Medicine, Microbiology & Immunology, & Pathology

Department of Internal Medicine

Virginia Commonwealth University

Title:   Monocyte Derived Immunosupressant Cells Inhibit Immune Regulation of Mast Cells in Mastocytosis


2011 TMS Research Award

This grant award was funded by TMS.

Award amount:         $52,516

Award recipient:

Lawrence Afrin, MD

Associate Professor of Medicine

Division of Hematology/Oncology

Medical University of South Carolina (MUSC)

(Currently Division of Hematology, Oncology, and Transplantation, University of Minnesota)

Collaborators:  John Lazarchick, MD, MUSC

Sally Self, M.D., MUSC

Elizabeth Hill, Ph.D., MUSC

Title:   Characterization of Certain Peripheral Blood Cell Abnormalities Potentially Aiding the Diagnosis of Mast Cell Activation Syndrome (MCAS)

Resulting Publication(s)/Presentation(s):

Afrin LB, Self S, Menk J, Lazarchick J. Characterization of Mast Cell Activation Syndrome.  Am J Med Sci 2017, in press, DOI: 10.1016/j.amjms.2016.12.013.

Afrin LB, Self S, Menk J, Lazarchick J. Characterization of Mast Cell Activation Syndrome. Blood 2016 128:3683.

Afrin LB, Butterfield JH, Raithel M, Molderings GJ. Often seen, rarely recognized: mast cell activation disease–a guide to diagnosis and therapeutic options. Ann Med. 2016;48(3):190-201.

Afrin LB, Wan Z, Hill EG. Characterization Of Common Blood Test Abnormalities Potentially Aiding Diagnosis Of Mast Cell Activation Syndrome: A Preliminary Analysis. Blood 2013 122:5240.


2010 TMS Research Award

This grant award was funded by TMS.

Award amount:         $50,000

Award recipient:

Peter Valent, MD

Karoline Gleixner, MD

Medical University of Vienna

Title:   Identification of a new target pathway in neoplastic mast cells as basis for the design of a novel pharmacologic concept

Resulting Publication(s)/Presentation(s):

Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hormann G, Rix U, Bennett KL, et al. KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood. 2011 Aug 18;118(7):1885-98.


2010 TMS Research Award

This grant award was funded by TMS.

Award amount:   $9,756

Award recipients:

Jonathan Smith, MD

Melissa Snyder, PhD

Michael Cutrer, MD

Joseph Butterfield, MD

Mayo Clinic, Rochester, MN

Title:   Cerebrospinal Fluid Tryptase and Neuropsychiatric Symptoms in Systemic Mastocytosis

Resulting Publication(s)/Presentation(s):

Smith JH, Snyder MR, Weiler CR, Cutrer FM, Butterfield JH. Lack of evidence for intrathecal tryptase synthesis in patients with systemic mastocytosis. J Allergy Clin Immunol. 2013 Oct;132(4):996-7.