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Pediatric Mastocytosis Fact Sheet


Pediatric Mastocytosis is a rare disease characterized by the presence of too many mast cells in the skin, and possibly other tissues. Mast cells are instrumental in mediating anaphylaxis, and children with mastocytosis are at risk to develop both provoked and unprovoked episodes of anaphylaxis. Pediatric mastocytosis may involve the bone marrow and the gastrointestinal tract, and symptoms in children can vary greatly from child to child. Basic treatment includes the avoidance of known triggers, having injectable epinephrine available at all times, H1 and H2 antihistamines to control itching and gastric acid hyper secretion, and a mast cell stabilizer. IV steroids may be necessary to treat progressive, severe bullae in infants. Many children may not complain of specific symptoms, may not be able to identify or localize a symptom, or may have every symptom while others may have very few.

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