Epinephrine may be titrated according to the severity of anaphylaxis symptoms:
NOTE: If no IV has been started ,
epinephrine should be given rapidly by
IM injection (vastus lateralis )
or endotracheal tube. The dose is 0.3ml
of 1 mg/ml solution repeat X3 at 5 min
intervals for systolic BP <90 mmHg.
- Grade I: None.
- Grade II: 10-20 mcg IV.
- Grade III: 100-200 mcg IV Q 1-2 min; 1-4 mcg/min
- Grade IV: 1-3 mg to 3-5 mg IV Q 3 min;
4-10 mcg/min infused.