Precautions For Mastocytosis
1. Mastocytosis patients may have
individualized drug sensitivities and
symptoms of anaphylaxis that are atypical.
2. Mast cell activation symptoms can quickly
disintegrate into anaphylaxis, and simple
symptoms should never be overlooked nor
should treatment be delayed.
3. Additional doses of H1 and H2 antihistamines
may be needed to control itching,
abdominal pain, nausea, diarrhea and
bloating even after acute anaphylaxis has
responded to treatment.
4. Control the patient’s environmental
temperature and stress to avoid setting off a
mast cell reaction again.
5. If the patient’s symptoms flare after the
initial reaction is treated, check all
parenteral medications to make sure that
none of them contain alcohol or
6. Any Beta blockers or drugs that interfere with
epinephrine or that contribute to histamine
release should be withheld.
7. If emergency surgery is needed,
mastocytosis patients should receive H1 and
H2 antihistamines, steroids, mast cell
stabilizers and leukotriene blockers